Valerie Flame (which is itself a part portrayed by Swedish-only speaking "actress" Ingrid Hagerstown as a show-within-a-show), Åkerman joined during the series' second season along with Henry Winkler.She played Constance Sack, a journalist who interviews Tom Cruise's character Stacee Jaxx.She hired a vocal coach as her role required her to sing; she and Cruise recorded a duet of Foreigner's "I Want to Know What Love Is" (1984).
In 2010, she became part of the main cast on the comedy series Childrens Hospital.
She starred in four feature films in 2012, including the comedy Wanderlust and the musical film Rock of Ages.
In 2012, she had a recurring role on the sitcom Suburgatory and starred in the short-lived comedy series Trophy Wife from 2013 to 2014, both of which aired on ABC.
She became known for making appearances in several Canadian productions.
In the early 2000s, she had many television and film parts, including The Utopian Society (2003) and Harold & Kumar Go to White Castle (2004).
Following a supporting role on the comedy series The Comeback (2005), Åkerman gained her first starring roles in the feature films The Heartbreak Kid (2007) and 27 Dresses (2008).
Åkerman played Silk Spectre II in the 2009 superhero film Watchmen, a role for which she was nominated for a Saturn Award for Best Supporting Actress.
Apart from acting and occasional modelling, Åkerman had a brief music career as the lead vocalist for alternative rock band The Petalstones, but eventually left to focus on her acting career.
She was married to the band's drummer Roberto Zincone from 2007 until 2013.